The new campus of SZABIST at Larkana opened in August 2004. It has a covered area of over 86,000 sq. feet and has an air-conditioned custom built auditorium, library, laboratories, classrooms, and cafeteria with separate hostel facilities for girls & boys. Current offering at SZABIST Larkana Campus includes BBA (Day) and MBA (Evening).

SZABIST Larkana Campus also houses the Intermediate College, which offers quality education in General Science and Commerce, and the Job Skill Training Center (JSTC) which offers diploma and certificate programs.